miRNAI

AI-driven development of microRNA (miRNA: small non-coding oligonucleotide molecules) therapeutics: cardioprotective miRNAs developed by Pharmahungary Group.

Development of therapeutic miRNAs: www.protectomir.com

Development of miRNA discovery tools: www.mirnatarget.com

 

Relevant publications:

1. Varga ZV, Zvara A, Faragó N, Kocsis GF, Pipicz M, Gáspár R, Bencsik P, Görbe A, Csonka C, Puskas LG, Thum T, Csont T, Ferdinandy P.
MicroRNAs associated with ischemia/reperfusion injury and cardioprotection by ischemic pre- and postconditioning: ProtectomiRs.
Am J Physiol Heart Circ Physiol. 2014 May 23. Link.

2. Varga ZV, Ágg B, Ferdinandy P.
miR-125b is a protectomiR: A rising star for acute cardioprotection.
J Mol Cell Cardiol. 2018 Feb;115:51-53. Link.

3. Makkos A, Ágg B, Petrovich B, Varga ZV, Görbe A, Ferdinandy P.
Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: involvement of redox signalling.
Free Radic Biol Med. 2021 May 6;S0891-5849(21)00280-X. Link.

4. Makkos A, Ágg B, Varga ZV, Giricz Z, Gyöngyösi M, Lukovic D, Schulz R, Barteková M, Görbe A, Ferdinandy P.
Molecular Network Approach Reveals Rictor as a Central Target of Cardiac ProtectomiRs.
Int J Mol Sci. 2021 Sep 2;22(17):9539. Link.

5. Bereczki Z, Benczik B, Balogh OM, Marton Sz, Puhl E, Pétervári M, Váczy-Földi M, Papp ZsT, Makkos A, Glass K, Locquet F, Euler G, Schulz R, Ferdinandy P, Ágg B.
Mitigating off-target effects of small RNAs: conventional approaches, network theory and artificial intelligence.
Br J Pharmacol. 2025 Jan;182(2):340-379. Link.

6. Nagy RN, Makkos A, Baranyai T, Giricz Z, Szabó M, Kravcsenko-Kiss B, Bereczki Z, Ágg B, Puskás LG, Faragó N, Schulz R, Gyöngyösi M, Lukovic D, Varga VZ, Görbe A, Ferdinandy P.
Cardioprotective MicroRNAs (ProtectomiRs) in a Pig Model of Acute Myocardial Infarction and Cardioprotection by Ischemic Conditioning: MiR-450a.
Br J Pharmacol. 2025 Jan;182(2):396-416. Link.

7.Szabados T, Makkos A, Ágg B, Benczik B, Brenner GB, Szabó M, Váradi B, Vörös I, Gömöri K, Varga ZV, Görbe A, Bencsik P, Ferdinandy P.
Pharmacokinetics and pharmacodynamics of intravenous miR-125b* mimic: cardioprotection in a mouse model of acute myocardial infarction.
Br J Pharmacol. 2025 Jan;182(2):432-450. Link.